Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model

Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model

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The Spontaneously Diabetic Torii (SDT) fatty rat is a new model for obese type 2 diabetes.The aim of the present study was to investigate the effect of 1/2 nephrectomy (Nx) on renal function and morphology and on blood pressure in SDT fatty rats.Male SDT fatty rats underwent 1/2 Nx or a sham operation (Sham).

Subsequently, animals were studied with Dollhouse Accessories respect to renal function and histological alterations.Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic kidney disease, at a younger age compared with the sham group.In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new RECONSTRUCTURING SHAMPOO drug discovery.